VEGFA and age-related macular degeneration: Additionally, Lf has been identified as a candidate to inhibit hypoxia-inducible factors (HIFs), whose main objective is based on the expression regulation of various genes, including VEGF and, consequently, they are considered as a target for treatment of neovascular ocular diseases such as age-related macular degeneration (AMD), diabetic retinopathy and diabetic macular edema [30].