ERBB2 and breast carcinoma: A similar study revealed that stable HCT-conjugated DTX NCs (HCT-DTX-NCs), with a pebble shape and mean particle size of 542.4 ± 195.0 nm, exhibited drug release behavior in a more rapid way, and increased cellular uptake and cytotoxicity in HER2-positive breast cancer cells than unconjugated DTX NCs [115].