VEGFA and arthritic joint disease: Recently, Zhang et al. demonstrated that the injection of both synovial mesenchymal cell (S-MSC)-derived exosomes or exosomes overexpressing circRNAs (Ad-circEDIL3) reduced synovial VEGF and consequently ameliorated arthritis severity in the CIA mouse model, by targeting the circEDIL3/miR-485-3p/PIAS3/STAT3/VEGF functional module in RA [217] (Figure 3).