The biokinetic evaluation of 177Lu2O3-iPSMA (Table 3) and 177Lu2O3-iFAP (Table 4) in nude mice bearing HCT116 tumors showed a statistically significant (p < 0.05) higher tumor retention of both nanosystems after intratumoral injection with regard to 177Lu2O3 nanoparticles (Table 5). This evidence concerns the gene MBTPS2 and neoplasm.