Additionally, CBD induces antiproliferative effects on tumor cells, mediated by a significant downregulation of PI3 K (Phosphoinositide 3-kinases)/Akt/mTOR (mammalian target of rapamycin) pathway, which promotes cell growth, proliferation, and survival and MAPK/ERK (extracellular signal-regulated kinases) pathway whose downstream targets are involved in the regulation of cell cycle entry and proliferation and the transcription of transcription factors, e.g., c-myc, CREB (cAMP response element-binding protein), and c-Fos. The gene discussed is CREB1; the disease is neoplasm.