FZD4 and retinal disorder: Overall, KIF11-associated retinopathy has many features that are different from FEVR, which has been proven to be caused by an interruption of the Wnt/β-catenin signaling pathway, which is formed by FZD4, the coreceptor gene LRP5, the FZD4 ligand gene Norrin and a component of the Norrin-FZD4 complex gene TSPAN12 [5,14].