INS and type 1 diabetes mellitus: T-lymphocyte-mediated insulitis, followed by the presence of one or more type of autoantibody (AAb) against insulin, glutamic acid decarboxylase (GAD), protein tyrosine phosphatase IA-2 or IA-2β, and zinc transporter 8 (ZnT8), is indicative of the immunological onset of T1D [1,3,4].