In contrast, in gnomAD BRCA1 c.5407-25T>A is infrequent in the non-cancer general population having a MAF of 7.46 × 10−6, and a carrier frequency of two out of 134,138 individuals from the non-Finnish European population, a population of ancestral origin closest to the ancestry of our cancer families. Here, BRCA1 is linked to cancer.