We also report the analysis of this variant in WES data from early-onset OC cases not selected for family history of cancer and OC cases from HBOC families, loss of heterozygosity (LOH) analyses of the BRCA1 locus in OC tumor DNA and WES analyses of peripheral blood lymphocyte (PBL) DNA of 10 other OC predisposing genes from variant carriers. This evidence concerns the gene BRCA1 and cancer.