MMP9 and malignant colon neoplasm: Interestingly, CDK8 stimulates expression of MMP-9 in human colon cancer cells via Wnt/β-catenin-driven transcription [41], while MED12 plays an important role in regulating and mediating the function of CDK8 kinase module, and the activation of CDK8 kinase also requires the participation of MED12 [42,43,44].