Ionta et al. [42] showed that exogenous Cx43 expression leads to a decrease in the growth of rat hepatocellular carcinoma cells and contributes to the reversion of the transformed phenotype, proposing that these effects were independent of GJIC formation capacity and probably associated with changes in the phosphorylation pattern and/or redistribution of the Cx43 protein in cellular compartments. This evidence concerns the gene GJA1 and hepatocellular carcinoma.