The available TCGA data uncovered that the levels of METTL3-A were upregulated in most other solid tumors (Figure S5A), while the levels of the METTL3-D variant were downregulated (Figure S5B), showing a similar pattern to those in HCC and suggesting that aberrant splicing of METTL3 is a common feature in solid tumors. Here, METTL3 is linked to hepatocellular carcinoma.