There is a spectrum of pubertal development reported in patients with POU1F1 variants, ranging from central precocious puberty (CPP) identified in two unrelated subjects with CPHD [23] up to the absent puberty in a 17-year-old male having severe untreated TSH and GH deficiencies, in whom puberty began spontaneously after adequate replacement of thyroid and growth hormones [47]. This evidence concerns the gene GH1 and central precocious puberty.