TAFAZZIN and Barth syndrome: Following bioinformatic prediction that TAZ belongs to a superfamily consisting of acyltransferases involved in phospholipid biosynthesis and/or remodeling [16], Vreken et al. reported that the CL levels were significantly decreased in cultured skin fibroblasts derived from BTHS patients, although the biosynthesis rates of CL and its processor phosphatidylglycerol (PG) were normal [8].