Besides, Androgen receptor (AR), Sp1, TP53, NF-KB1, STAT3, RELA and signature microRNAs such as miR-21-5p, miR-125a-5p, miR145-5p and miR-155-5p have been reported jointly in the same study for the first time in PCa tissue samples as tumor markers and clinical targets. The gene discussed is SP1; the disease is posterior cortical atrophy.