SQSTM1 and hepatocellular carcinoma: In order to verify whether RELA and SQSTM1 may serve as reliable biomarkers in HCC, we further performed a diagnostic receiver operative characteristic (ROC) analysis, as shown in Figure 8D, in which we followed the philosophy of the gold-standard test (i.e., dichotomization of the mentioned samples in TCGA cohort and GTEx portal into disease present, which includes all tumor grades from G1 to G4, or disease absent meaning that the sample is normal) [49,50].