HECTD1 and rheumatoid arthritis: In addition, six lncRNAs (QKI, EPC1, TNFSF10, DDX3X, RC3H1-IT1, and BRWD1-IT1) and six mRNAs (SMG1, LCOR, IPMK, RICTOR, KIF5B, and HECTD1) were confirmed to play a role in the destruction of cartilage or the promotion of inflammation [47,48,49,50,51,52,53,54,55,56,57,58], which indirectly supports their association with RA.