AKT1 and rheumatoid arthritis: To be specific, for the mTOR pathway, which has with prominent statistical significance in Figure 4, Kun Chen carried out a study that showed that metformin arrests the G2/M cell cycle of FLS by downregulating the IGF-IR/PI3K/AKT/mTOR pathway, thereby inhibiting the proliferation of FLS and alleviating the progression of RA [59].