CRTC2 and rheumatoid arthritis: However, in this study (Figure 4), the protein functions related to noncanonical signaling pathways (protein localization to the microtubule organizing center, rho GTPase binding, the TORC2 complex, the TOR complex, the phosphatidylinositol signaling system) showed more considerable statistical significance than the protein functions related to the canonical signaling pathways (β-catenin destruction complex), which suggests that the noncanonical signaling pathways may be even more critical for RA than canonical signaling pathways, or at least as necessary.