A significant association was observed between the serotonin transporter gene SLC6A4 (genetic variants: 5-HTTLPR, rs140700, rs4251417, rs6354, rs25528, rs25531) and DNA methylation at various CpG sites, which suggests DNA methylation-associated depression status in a community-based population study of older individuals. This evidence concerns the gene SLC6A4 and depressive disorder.