While TP53 alterations might be observed in response to treatment or with an intrinsic link with age [17], multiple teams have demonstrated that chromosomal abnormalities affecting the TP53 gene (exon 5 to 8), notably missense mutations or duplication, did not include any association between a specific TP53 mutation type or any MPN subtype [157]. This evidence concerns the gene TP53 and myeloproliferative neoplasm.