Among the increasing panel of additional mutations that might be implicated in the development or the progression of hematological malignancies, genetic alterations affecting epigenetic regulators, specifically DNA methylation and chromatin modification genes including TET2, DNMT3A, IDH1/2, ASXL1, and EZH2, were described as more frequent in PV than in other MPNs [114]. This evidence concerns the gene DNMT3A and acquired polycythemia vera.