SH2B3 and acquired polycythemia vera: In addition, an SH2B3 mutation was observed in one JAK2V617F-negative patient with PV syndrome [85], but it most often coexists in patients with a JAK2V617F-mutated PV pathology [9], or other genes (TET2, ASXL1), indicating that they may also cooperate with other mutations to induce the associated phenotype.