DLK2 and cancer: Moreover, the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed that DLK2 were positively modulated in the gene networks that participated in ribosome biogenesis, splicesome formation, protein digestion/absorption, axon guidance, cytokine–cytokine receptor interaction, transcriptional misregulation of cancer, and pathways in cancer (Figure 8C), and lysosome-/carbon metabolism-/oxidative phosphorylation-related gene networks was negatively regulated by DLK2 in ccRCC.