From the Panther pathway and Pearson’s correlation analyses based on the LinkedOmics database, DLK2 signaling may positively regulate the TGF-β1 and Notch signaling pathways, and it has been reported that an extensive cross-talk between the TGF-β1 and Notch signaling cascades is associated with the aggressiveness of ccRCC [51]. The gene discussed is DLK2; the disease is nonpapillary renal cell carcinoma.