Furthermore, the development of ccRCC is related to multiple gene dysregulations, such as polybromo-1 (PBRM1), BRCA1-associated protein 1 (BAP1), SET domain-containing 2 (SETD2), transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) (TCEB1), lysine (K)-specific demethylase 5C (KDM5C), and Von Hippel–Lindau Tumor Suppressor (VHL) [6]. The gene discussed is KDM5C; the disease is nonpapillary renal cell carcinoma.