A total of 67 genes associated with liver carcinoma exhibited direct interactions with 28 HLHS candidate genes, including 7 novel interactions (listed in the format HLHS candidate gene-liver carcinoma-associated gene: NRDC-IRS1, RPS6KA1-CXCL12, NIF3L1-CXCL12, STT3B-GNMT, ZAN-TFPI2, COL15A1-PDGFB and MFSD6-STAT1). This evidence concerns the gene TFPI2 and hepatocellular carcinoma.