Four genes identified to be associated with HLHS in independent studies [15,17,18,20] were retrieved as known interactors of our HLHS candidate genes (shown in bold): EP300-PROX1, TSC1-POGZ, HNRNPAB-RBFOX2 and PSEN1-RYR2. The gene discussed is TSC1; the disease is hypoplastic left heart syndrome.