In particular, in this third molecular type fall pleomorphic-xantoastrocytoma (PXA)-like pHGGs, v-myc myelocytomatosis viral-related oncogene (NMYC), platelet-derived growth factor receptor A (PDGFRA), or EGFR amplified gliomas and hypermutant pHGGs [5,22]. This evidence concerns the gene EGFR and central nervous system cancer.