Three tumors (27%) (P2, P5 and P9) are classified in the H3.3K27M mutant sub-type, two (18%) (P10 and P11) in the H3.3G34R/V mutant sub-type, one (9%) (P3) in the IDH mutant sub-type (Figure 1), one (9%) (P6) as a PXA-like pHGG, and one (9%) (P4) as a diffuse midline glioma EGFR mutant (Figure 2). The gene discussed is IDH2; the disease is diffuse midline glioma.