Tumor-harboring Gly34Arg/Val variants are typically hemispheric and, when compared with H3.3K27M mutated gliomas, affect older age group (teenagers and young adults); they are associated with a slightly prolonged survival, possibly related to MGMT methylation, resulting in enhanced responsiveness to temozolomide [1,16,17]. The gene discussed is MGMT; the disease is central nervous system cancer.