IDH2 and brain neoplasm: P3 presents a complex pattern of variants, and we identified a new VUS (c.863C>T p.Ala288Val) in exon 2 of the TERT (Telomerase reverse transcriptase) gene, as well as a pathogenic variant in exon 4 of the IDH2 gene (c.419G>A p.Arg140Gln) associated with hematopoietic neoplasms/MDS, lung, stomach and upper aero-digestive tract tumors (COSM41590); however, these were never reported in brain tumors.