FCGR1A, FCGR1B, FCGR1C, BATF2, GBP1, ANKRD22, GBP5, AIM2, GBP6, and CASP4, were ranked among the top overexpressed genes in ATB compared to LTBI, whereas NDRG2, KLF12, ANO9, CD79A,FCGBP,GZMK,CXCR3, MIEF2, CXCR5, and CD27 genes were the most downregulated genes in active TB vs. LTBI. The gene discussed is GBP5; the disease is tuberculosis.