DKK3 and inborn error of immunity: The enriched GO term/pathway analysis revealed that the downregulated genes were primarily involved in Wnt signaling (WNT7A, CSNK1E, DKK3, TCF7, and TLE2), CD19, CD79A, CD8B, and TNFRSF13C), primary immunodeficiency (CD19, CD79A, CD8B, and TNFRSF13C), immune response (CXCR5, CD27, CD8B, TNFRSF25, NCR3, VPREB3, and TCF7), cytokine-cytokine receptor interaction (CXCR3, CXCR5, CD27, TNFRSF13C, TNFRSF25, IL11RA, and IL23A), regulation of cell proliferation (BLK, CD27, TNFRSF25, LAMA5, and TCF7), and B cell receptor signaling pathway (BLK, CD19, and CD79A) (Figure 2C).