BRD2 and premature menopause: The loss of ovarian function in women, referred to as premature ovarian insufficiency (POI, OMIM #311360), is associated with oligomenorrhea/amenorrhea, sometimes with hypoplastic ovaries undetectable upon pelvic ultrasound, elevated gonadotropins (particularly FSH) in repeated blood tests (>4 weeks apart), and low sex steroid hormone levels (particularly estradiol) before age 40 [1,2,3] (https://www.eshre.eu/Guidelines-and-Legal/Guidelines/Management-of-premature-ovarian-insufficiency.aspx, accessed on 1 March 2022).