The genetics of hyperuricemia, which is universally accepted to be the cause of gout, involves genes such as SLC2A9 (encodes for GLUT9), SLC22A12 (encodes for URAT1), SLC22A13 (encodes for OAT4) and ABCG2; these are mostly involved in uric acid reabsorption and secretion. This evidence concerns the gene SLC22A12 and hyperuricemia.