CRP and Renal insufficiency: Clinical findings suggestive of IE in patients with VO have been reported to be related to back pain [10], neurologic complications [8], cardiac comorbidities (e.g., valvular disease and pacemakers) [2,9,11], renal failure [2], dialysis [2,9], glomerulonephritis (reported incidence from 0% to 46%) [3], sepsis [2,9], and C-reactive protein levels [11].