In addition, loss of E-cadherin expression seems to be an oversimplification because, surprisingly, several metastases still contain high levels of E-cadherin, and epithelial cells expressing E-cadherin can become invasive and metastasize, notably in patients with prostate cancer [75], ovarian cancer [76] and glioblastoma [77]. This evidence concerns the gene CDH1 and glioblastoma.