CDH1 and cancer: Interestingly, the expression levels of circRNAs, member of the non-coding RNA family, were upregulated in cancer tissues of SACC patients; cell transfection techniques, used to inhibit the expression of circRNA members in SACC cell lines, demonstrated that the proliferative, invasive and migratory abilities of SACC cells were significantly decreased, and the EMT process was inhibited, affecting E-cadherin expression [67].