MEN1 and familial isolated pituitary adenoma: However, growing evidence has demonstrated that several syndromic conditions, including the McCune–Albright syndrome (MAS) [48,49], Carney complex (CNC) [50,51], and rarely multiple endocrine neoplasia type 1 (MEN1) [52] and familial isolated pituitary adenomas (FIPA) [53], lead to GH excess through pituitary hyperplasia that appears to precede tumor development.