Indeed, patient 2 had optic and hypothalamic lesions, likely representing gliomas, and a 4 mm right pituitary tumor that was resected with pathology negative for GH and biochemically persistent GH excess post-surgery, likely due to increased hypothalamic GHRH release versus the loss of somatostatin tone from the infiltrating lesions. The gene discussed is GHRH; the disease is central nervous system cancer.