Positivity in one of the criteria aPL (LAC, aCL IgG, aCL IgM, aβ2GPI IgG, and aβ2GPI IgM) is sufficient for diagnosing APS in presence of a clinical criterion [36,44], although antibody isotype, titer and number of positive tests also give useful information for thrombotic and obstetric risk stratification [44]. This evidence concerns the gene LCT and autoimmune polyendocrinopathy.