Further, ligand-based CAR recognition domains have been introduced to target BCMA via trimeric APRIL [46], and the small chlorotoxin, a naturally derived 36-amino-acid-long peptide found in the venom of the death stalker scorpion leiurus quinquestriatus, which selectively binds to primary brain cancers is used for the treatment of glioblastoma (GBM) [47]. The gene discussed is TNFRSF17; the disease is glioblastoma.