Looking at the whole map, UBE2SP1 appears to be the most influential node of the basal sub-network, as it spans some of the previously mentioned contexts, especially metabolism through IQGAP3 (IQ Motif Containing GTPase Activating Protein 3), ubiquitously overexpressed in several human cancers, and ARHGAP11A (Rho GTPase Activating Protein 11A), relevant for cell cycle arrest and apoptosis and specifically known to be highly expressed in a human basal-like BC cell line. The gene discussed is UBE2SP1; the disease is cancer.