The M1 response was higher during LdCen-/- infection, compared to WT L. donovani infection, and was characterized by the upregulation of inflammatory mediator transcripts (IL-1β, IL-12, TNF-α, and iNOS2) and the downregulation of M2-related genes (IL-10, YM1, Arg-1, and MRC-1 genes). Here, IL10 is linked to infection.