The recurrently amplified segment of chromosome 3q also harbors two genes that are frequently co-amplified in HNSCC: TP63, a key regulator of epidermal cell differentiation and proliferation [97], and ACTL6A, a subunit of the SWI/SNF ATP-dependent chromatin remodeling complexes [98]. The gene discussed is TP63; the disease is head and neck squamous cell carcinoma.