Consistent with mechanistic models in which PIK3CA activation induces downstream YAP dephosphorylation and nuclear translocation to drive YAP-mediated transcription programs, HNSCC tumor samples with high PIK3CA expression displayed lower abundances of p-YAP and PIK3CAhigh tumors expressed transcriptional programs enriched for YAP/TAZ target genes [108]. Here, WWTR1 is linked to head and neck squamous cell carcinoma.