SIRT1 and Alzheimer disease: BACE1, SP1, NCSTN, PTEN, and SIRT1 are also regulated by miRNAs implicated in AD, with miR-9, miR-16, miR-34a, miR-106a, miR-107, miR-125b, miR146, and miR-181c presenting the highest level of interactions in the network [221].