Alternatively, among mild cognitive impaired type 2 diabetic patients, enhanced plasma activity of the enzyme dipeptidyl peptidase-4 (DPP4), known to enhance inflammation and oxidative stress, is negatively linked with circulating brain-derived neurotrophic factor (BDNF) levels, and positively correlates with inflammatory markers (i.e., IL-6, CRP) and cognitive impairment [179,180]. The gene discussed is IL6; the disease is Cognitive impairment.