APP and Alzheimer disease: Moreover, the downregulation of three miRNAs that modulate target proteins related to AD, such as APP and CaMKK2 (hsa-miR-9-5p, hsa-miR-106a-5p, and hsa-miR-106b-5p), have been correlated with disease severity; hsa-miR-106a-5p alone reaching statistic values of 93% specificity and 68% sensitivity in AD diagnosis [223].