TGFB1 and cancer: The activation of the canonical TGF-β pathway through the addition of exogenous TGF-β to cancer RDEB keratinocytes seems to arrest cellular proliferation, while the inhibition of the same pathway at an intracellular level drives different and apparently controversial cellular responses, thus suggesting the existence of an intricate intracellular network of pathways regulated by TGF-β that we may not yet completely understand [26].