We focused on the antioxidant enzyme PRDX4, a protein that was highly upregulated in lysates obtained from CRP4 null lysates, because its overexpression reportedly correlated with cell protective, plaque stabilizing effects in atherosclerosis as well as the attenuated formation of lesions [56,74] and oxidative stress [73,75]. This evidence concerns the gene PRDX4 and atherosclerosis.