PTEN and metastatic melanoma: HT1080 fibrosarcoma cells are known to be homozygous for CDKN2A deletion, to have an activated N-ras oncoprotein (p.Gln61Lys), and carry a p.Arg132Cys IDH1 mutation, whereas WM266-4 metastatic melanoma bear a PTEN hemizygous deletion and a BRAF p.Val600Asp mutation (https://web.expasy.org/cellosaurus/, last accessed on 1 December 2021).