LONP1 and cancer: In human cancer cells, genetic downregulation of LonP1 by siRNA in HT1080 fibrosarcoma cells was found to cause a variety of transcriptional changes in genes belonging to a wide spectrum of cellular stress–response mechanisms, such as the mitochondrial unfolded protein response, but also the cytoplasm-based pathways of the integrated stress response, heat shock response, and antioxidant response.