These include the mitochondrial and endoplasmic reticulum unfolded protein responses (UPRmt, UPRER), the integrated stress response (ISR), the heat shock response (HSR), the antioxidant response (AR), etc. To study the effect of LonP1 disruption in cancer cells, we tested the types of responses generated by LonP1 downregulation, first by genetic knockdown and then using CDDO-Me to pharmacologically inhibit the protease. The gene discussed is LONP1; the disease is cancer.