NFKB1 and Anxiety: Proinflammatory markers, such as CCR2, lipoteichoic acid (which induces the secretion of cytokines including IL-1β and TNF-α that can contribute to the blood–brain barrier disruption), IL-22ra2, and nuclear factor-kB (NF-kB), are associated with the pathophysiology of inflammatory bowel syndrome and play a key role in anxiety-like behavior in a murine model of chronic social stress [68].