CTSK and osteosarcoma: To further examine whether the inhibition of YAP/TAZ signaling by VP can inhibit osteosarcoma proliferation, migration, and invasion in vitro, we first treated the primary osteosarcoma cells from Ctsk-Cre;Trp53f/f/Rb1f/f mice with 0, 0.1, 1 and 2 μM VP for 0, 1 and 2 days.