Viral genome was detected in the basal medium at 48 hpi and onward (Figure 7c), in agreement with SARS-CoV-2 detection at the apical side, strongly present in wt/wt-CFTR while weakly detected in F508del/F508del-CFTR even at 72 hpi, indirectly confirming the breach of epithelial integrity caused by the infection more pronounced in wt/wt-CFTR than in F508del/F508del-CFTR MucilAirTM, previously highlighted through TEER measurements. Here, CFTR is linked to infection.