The sharp increase in wt/wt-CFTR MucilAirTM viral replication correlated with a reduction in epithelium integrity at 48 but mostly at 72 hpi, reflected by 1.2- and 2.9-fold decreases in TEER values, respectively, while in F508del/F508del-CFTR MucilAirTM the TEER values remain consistent with the passing of hours after infection (1.4- fold decrease at 72 hpi) stating greater maintenance of epithelium integrity (Figure 7b). This evidence concerns the gene CFTR and infection.