CDKN2A and type 2 diabetes mellitus: Accordingly, the genetic locus in which the CDKN2A gene is localized constitutes a classical and reproducible hotspot for genome-wide association studies (GWASs) investigating the association of lifestyle-related diseases and age-related chronic pathologies like type 2-diabetes, Alzheimer’s disease, atherosclerosis, coronary artery disease, and other human disorders [172,174,175,176,177].