H19 and neoplasm: However, the precise molecular mechanism is not completely known, and also it has not been understood if this oncogenesis promotion is achieved per se or through the activities of miR-675-3p and miR-675-5p (of which H19 is a precursor), which specifically target tumor suppressor genes such as the retinoblastoma protein Rb, Runx1, and Cadherin 13 [266,267,268].