The recently identified LncRNA-ZXF1 transcribed from chromosome 10 and altered in several cancers has been shown to function through two distinct mechanisms: on one side it works as a miR-378a-3p sponge increasing the expression of the miRNA targeting PCDHA3, on the other side it binds to p21Cip1/Waf1 preventing the APC/C(Cdc20)-mediated degradation [350]. Here, CDKN1A is linked to cancer.