LncRNAs exerting their regulative role on p21Cip1/Waf1 acting as a miRNA sponge include LINC00460, found overexpressed in a variety of human cancers, including head and neck squamous cell carcinoma (HNSCC), where it is able to affect cell proliferation and cell cycle control through a sponge effect on miR-612 and an indirect p21Cip1/Waf1 downregulation mediated by reducing the miR-612/AKT2 axial [359]. The gene discussed is CDKN1A; the disease is cancer.