TGM2 and neoplasm: With regard to tumor progression, the mesenchymal transdifferentiation (MT) plays an important role, and a contribution of TG2 to this process via regulation of C/EBPb signaling was demonstrated by Yin et al. in 2017 [30], and is also being discussed because of the TG2 activation potential for TGF-β1, FAK and AKT, which represent well-known mediators of the MT [2,28].