Of importance, GPR158 appears to be correlated with ageing and cardiac diseases caused by aFGF (acidic fibroblast growth factor)-induced collagen deposition [73] and associated with the atrophy pattern [82] and Alzheimer’s Disease [83], which may be indicative for GPR158 in age-onset diseases [84]. This evidence concerns the gene FGF1 and early-onset autosomal dominant Alzheimer disease.