ORAI1 and Familial prostate cancer: Hence, Orai1 is overexpressed in oral/oropharyngeal squamous cell carcinoma cells (OSCC) [119,120], liver [121], and breast cancer cells [122,123], Orai2 expression is increased in gastric [124], breast [125], oral [120], and acute myeloid leukemia cancer cells [126], while Orai3 expression is enhanced in the luminal breast cancer subtype [123,127], as well as in lung [128], pancreatic [129], and prostate cancer cells [130] (for a more extensive review see [131,132,133,134,135]).