AKT1 and cancer: Several pathways are involved in cancer development, including the VEGF receptor pathway that can activate the RAS/RAF/MEK/ERK pathway [6] and the fibroblast growth factor (FGF) receptor pathway that activates multiple downward pathways, including the PI3K/Akt/mTOR, RAS/RAF/MEK/ERK and signal transducer and activator of transcription (STAT) pathways [7].