In the case of the FXS, the inhibitory effect of FMRP is lost, supporting local protein synthesis of proteins such as Arc, Map1B, CamKII, postsynaptic density-95 (PSD-95), matrix metalloproteinase 9 (MMP9), and glycogen synthase kinase 3 beta (GSK3β). The gene discussed is FMR1; the disease is fragile X syndrome.