P53, the most commonly mutated tumor suppressor gene in human cancers, positively regulates autophagy in DNA-damaged cells through AMPK activation of the TSC1/TSC2 complex and subsequent inhibition of mTOR, or via upregulation of damage-regulated autophagy modulator (DRAM), a lysosomal protein that may induce autophagy [7,8]. Here, DRAM1 is linked to cancer.