SERPINE1 and Insulin resistance: Adipokines include adiponectin, a protein hormone involved in the regulation of glucose levels and fatty acid turnover [25]; the plasminogen activator inhibitor-1 (PAI-1), a serine protease that inhibits fibrinolysis and induces insulin resistance and metabolic deviations [26]; and the pro-inflammatory factors interleukin-6 (IL-6) and the monocyte chemoattractant protein 1 (MCP-1).