CREB3L1 and thyroid gland undifferentiated (anaplastic) carcinoma: Nevertheless, in anaplastic thyroid cancer (ATC), where cells exhibit stem cell–like properties and NIS gene expression is totally silenced [45], copy number gain of the specific region of the Chr11 that include CREB3L1 gene and high levels of CREB3L1 expression were detected [46,47].