AQP3 and AQP5 were also correlated with increased levels of epidermal growth factor receptor (EGFR), proliferation marker protein Ki-67 (Ki-67), cytokeratin 7 (CK7), and vimentin (Vim), as well as decreased E-caderin (E-cad) [16], suggesting contribution to the epithelial-mesenchymal transition (EMT) process, tumor formation, and invasion. This evidence concerns the gene MKI67 and neoplasm.