TNF and rheumatoid arthritis: As synovial fibroblasts appear to express several GSDMs (based on gene expression data in [278]), it is possible that they would undergo pyroptosis during RA, either following the expression and activation of the NLRP3 inflammasome, as reported after repeated flares [277], or upon cleavage of GSDMs by an NLRP3-independent pathways, for example, downstream of the TNF-CASP8 signalling axis or upon cleavage by other enzymes such as granzymes, if delivered by activated T cells or NK cells.