The fact that TNF-induced lethality shows a GSDMD dependency, where GsdmdD88A mice succumb with faster kinetics compared to WT counterparts, and Gsdmd−/− mice are protected [191,211], highlights GSDMD as a possible therapeutical candidate for TNF-associated diseases such as rheumatoid arthritis. The gene discussed is GSDMD; the disease is rheumatoid arthritis.