TNF and arthritic joint disease: While these findings suggest a role of GSDMD in injury-induced rather than in antibody-induced arthritis, another preprint study employed the chemical GSDMD inhibitor disulfiram (DSF) in a type II collagen-induced arthritis model [241,242], and observed reduction of disease incidence, loss of cartilage, joint swelling and pro-inflammatory cytokines (IL-1β, IL6, IL-8 and TNF) upon DSF treatment [241].